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Dopamine blocks T-type calcium channels in cultured rat adrenal glomerulosa cells
O N Osipenko1, P Várnai, A Mike
1Department of Pharmacology, Hungarian Academy of Sciences, Budapest.
Endocrinology
|January 1, 1994
Abstract:
Dopamine is known to inhibit aldosterone secretion. In the present study using whole-cell voltage-clamp technique we found that dopamine, bromocriptine and quinpirole inhibit low-threshold (T-type) voltage dependent Ca2+ channels. The inhibiton was sustained and reversible, and it was prevented by sulpiride. These findings indicate that the effect of dopamine was mediated via DA2 receptors.