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Related Experiment Videos

Early evolutionary origin of major homeodomain sequence classes

C Kappen1, K Schughart, F H Ruddle

  • 1Department of Biochemistry and Molecular Biology, Mayo Clinic/Foundation, Scottsdale, Arizona 85259.

Genomics
|October 1, 1993
PubMed
Summary

This study classifies 337 homeodomain sequences into 30+ classes using a distance matrix. These distinct homeodomain sequence classes, found across diverse organisms, likely originated early in evolutionary history.

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Area of Science:

  • Molecular Biology
  • Evolutionary Biology
  • Bioinformatics

Background:

  • Homeodomain proteins are crucial transcription factors involved in development.
  • Understanding homeodomain sequence relationships is key to deciphering their evolutionary history.

Purpose of the Study:

  • To classify homeodomain and related sequences based on evolutionary relationships.
  • To investigate the early establishment of homeodomain sequence classes.

Main Methods:

  • Analysis of 337 homeodomain and related sequences.
  • Application of a distance matrix approach for sequence comparison.

Main Results:

  • Identification of at least 30 distinguishable classes of homeodomain sequences.

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  • High similarity within classes, but limited relationships between separate classes.
  • Presence of sequences from diverged organisms within the same classes.

    • Conclusions:

    • Homeodomain sequences were established early in evolution.
    • The identified classes represent ancient evolutionary lineages.
    • Further research can explore the functional implications of these early-established classes.