Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Evolutionary relationships among the serpins

C J Marshall1

  • 1Department of Biochemistry, University of Otago, Dunedin, New Zealand.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|October 29, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synopsis of a Report on Osteoporosis.

The Journal of comparative medicine and veterinary archives·2022
Same author

Pennsylvania State Veterinary Medical Association.

The Journal of comparative medicine and veterinary archives·2022
Same author

Modified Milk for Young Animals.

The Journal of comparative medicine and veterinary archives·2022
Same author

Evaluation of PEETER V1.0 urine sensors for measuring individual urination behavior of dairy cows.

JDS communications·2022
Same author

Urine and fecal excretion patterns of dairy cows divergent for milk urea nitrogen breeding values consuming either a plantain or ryegrass diet.

Journal of dairy science·2022
Same author

Grazing dairy cows with low milk urea nitrogen breeding values excrete less urinary urea nitrogen.

The Science of the total environment·2020
Same journal

The microlandscapes of tree trunks: the effect of lichen and tree-level characteristics on arthropod communities.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
Same journal

Centimetre-scale landscapes to assess the motion behaviour and cognition of gastropods and bivalves.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
Same journal

Intertidal microcosms of wave-swept rocky shores: ecological and physiological insights from a uniquely stressful environment.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
Same journal

Temporal and spatial variation in temperature and oxygen at the microscale: key niche axes for aquatic life.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
Same journal

Natural microcosms in ecology: fulfilling the promise of model systems?

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
Same journal

Microbe-induced galls and plant defence: metabolite crosstalk in a co-evolutionary battle.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
See all related articles

Serine proteinase inhibitors (serpins) show conserved sequences and structures across diverse species. Phylogenetic analysis reveals significant evolutionary diversity between plant and mammalian serpins, highlighting constrained molecular architecture.

Area of Science:

  • Biochemistry
  • Evolutionary Biology
  • Structural Biology

Background:

  • Serpins are a diverse group of serine proteinase inhibitors.
  • They are found across a wide range of organisms, including plants, birds, mammals, and viruses.
  • Despite evolutionary divergence, serpins exhibit high conservation in sequence and structure.

Purpose of the Study:

  • To align amino acid sequences of serpins using computational and structural methods.
  • To investigate the phylogenetic relationships among serpins from different organisms.
  • To assess the reliability of sequence alignments through 3D structure superposition.

Main Methods:

  • Combined automatic algorithms and conserved structural elements for sequence alignment.
  • Utilized the HOMED program for simultaneous alignment of amino acid and nucleotide sequences.

Related Experiment Videos

  • Employed maximum parsimony for phylogenetic analysis based on nucleotide sequences.
  • Superimposed known 3D serpin structures to validate sequence alignment reliability.

    • Main Results:

    • Generated reliable sequence alignments for serpins.
    • Constructed a phylogenetic gene tree based on aligned nucleotide sequences.
    • Identified significant evolutionary diversity between plant and mammalian serpins.
    • Observed comparable diversity within mammalian serpins.

    Conclusions:

    • The study provides evidence for highly constrained serpin molecular architecture.
    • Phylogenetic analysis supports substantial evolutionary divergence among serpins.
    • The findings contribute to understanding serpin evolution and structural conservation.