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Toxic pustuloderma induced by ofloxacin
1Department of Dermatology, Kurume University School of Medicine, Japan.
Abstract:
A patient with drug-induced toxic pustuloderma is presented. The patient, who was asthmatic and who was being treated with ofloxacin for bronchitis and pharyngitis, developed intense erythemas followed by subcorneal pustulation associated with fever and a neutrophil leukocytosis. The diagnosis was confirmed by oral readministration of ofloxacin, with the result that pustular eruptions were induced. This form of drug eruption had not previously been attributed to ofloxacin.
Insights
A patient developed toxic pustuloderma, a rare skin reaction, after taking ofloxacin for infections. This adverse drug event, characterized by pustules and fever, was confirmed by re-administering the antibiotic.
Area of Science:
- Dermatology
- Pharmacology
- Internal Medicine
Background:
- Toxic pustuloderma is a rare but severe skin reaction.
- Drug-induced skin reactions require careful identification and management.
- Ofloxacin is a commonly prescribed fluoroquinolone antibiotic.
Observation:
- A patient with asthma developed intense erythemas and subcorneal pustulation after receiving ofloxacin for bronchitis and pharyngitis.
- The patient also experienced fever and neutrophil leukocytosis, indicative of an inflammatory response.
- The adverse reaction was confirmed via oral re-administration of ofloxacin, which successfully induced pustular eruptions.
Findings:
- Ofloxacin can induce toxic pustuloderma, a previously unreported adverse drug reaction.
- The clinical presentation included fever and leukocytosis, consistent with a systemic inflammatory response.
- Re-challenge with ofloxacin confirmed its causative role in the patient's pustular eruption.
Implications:
- This case highlights the importance of considering ofloxacin as a potential cause of toxic pustuloderma.
- Clinicians should be vigilant for this rare adverse drug reaction, especially in patients with pre-existing inflammatory conditions.
- Further investigation may be warranted to understand the specific mechanisms underlying ofloxacin-induced toxic pustuloderma.