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Published on: September 17, 2015
The purely chronotropic effects of relaxin in the rat isolated heart
1Department of Cardiovascular Research, Genentech Inc., South San Francisco, CA 94080.
The Journal of Pharmacy and Pharmacology
|October 1, 1993
Abstract:
The endogenously occurring protein relaxin was evaluated for its cardiac effects in the rat isolated heart. Relaxin caused a dose-dependent tachycardia without positive inotropic effects in intact preparations and in preparations where the atria had been removed. It is concluded that relaxin acts on both the atrial and ventricular pacemakers to increase heart rate, but the precise mechanism of action remains unknown.
