Hemodynamic effects of terazosin in congestive heart failure

To determine the hemodynamic effects of a new alpha-1 blocker, terazosin, in congestive heart failure, 10 patients with this condition underwent hemodynamic testing at rest. Thirty minutes after the oral administration of 4 mg terazosin, mean right atrial pressure, mean pulmonary artery pressure and pulmonary capillary wedge pressure were found to be decreased, while the cardiac index was increased significantly. Improvement in hemodynamics persisted for more than 15 h, without an increase in heart rate. It is suggested that terazosin may have effective applications in the treatment of congestive heart failure.