[Radioprotective effect of alpha 2- adrenoreceptor agonists]

It is confirmed in experiments with selective antagonists, that radioprotective effects (RPE) of phenylephrine is realised by means of alpha 1--and RPE of clonidine--by means of alpha 2-adrenoceptors (AR). Guanobenz, more selective alpha 2-agonist with another structure, has high RPE too. Chemical analogues of clonidine (alpha-antagonist phentolamine, L-DOPA, DOP-serine), which don't cause selective stimulation of alpha 2-AR, don't protect mice. alpha 2-Agonists are new effective group of radioprotectors.