Hematological effects of aluminum on living organisms

1. Aluminum has been of great interest for many researchers over a number of years; its biochemical and physiological role is not yet fully clear. There are few papers describing the hematological consequences of its excess in living organisms and most of their data are cited in this paper. 2. Aluminum reduced the deformability of erythrocytes, and such cells are rather frequently retained in the reticuloendothelial system of the spleen and eliminated faster from the blood stream. 3. Aluminum produces peroxidative changes in the erythrocytes membrane, leading to hemolysis. Therefore, the depressed erythrocyte count in animals intoxicated with aluminum may be the consequence of both the hemolytic action of aluminum and the shortened time of survival of erythrocytes. 4. It was demonstrated that aluminum inhibits heme biosynthesis in vitro. This problem requires, however, further studies and observation. 5. Changes occurring under the influence of Al3+ on the leukocyte system of animals suggest the influence of this element on the resistance of the organism, but the mechanism of the action of Al3+ still requires elucidation. 6. Cell metabolism including blood cells may be affected by aluminum in many ways, the more so as the element may combine in vitro with amino acids, peptides, proteins, enzymes, substrates, cofactors, nucleotides and carbohydrates. Aluminum stimulates NADPH oxidation and takes part in the process of free radical formation.