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[Survival of patients with zidovudine resistant HIV]
P C Gøtzsche1, C Nielsen, J Gerstoft
1Epidemiafdeling M, Rigshospitalet, København.
Ugeskrift for Laeger
|January 10, 1994
Abstract:
The survival of 35 patients with AIDS or advanced HIV infection on zidovudine treatment was related to the viral sensitivity to the drug and to the CD4+ cell count. Fourteen patients died, the survivors were followed up for an average of 804 days. In a univariate Cox model, survival was strongly related to log IC90 (p = 0.0003) and to the CD4+ count (p = 0.0002). In a bivariate model, log IC90 and the CD4+ count contributed to the prediction of survival (p = 0.12 and 0.06, respectively). Large studies of combination or alternation therapy with several anti-HIV-drugs should be given high priority.