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Convulsant doses of cocaine alter immediate early gene and opioid peptide expression in rat limbic forebrain
T E Helton1, J B Daunais, J F McGinty
1Department of Anatomy and Cell Biology, East Carolina University School of Medicine, Greenville, NC 27858-4354.
Brain Research. Molecular Brain Research
|November 1, 1993
Abstract:
Rats were treated with escalating doses of cocaine until they experienced a convulsion and were euthanized 1 or 3 h after the last injection. Quantitative in situ hybridization histochemistry revealed that c-fos and zif/268 mRNAs were induced at 1 h in many limbic structures and declined 3 h after cocaine-induced convulsions. Preprodynorphin and preproenkephalin signals increased in many of the same structures 3 h, but not 1 h, after cocaine-induced convulsions.