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Complement and neutrophil activation during cardiopulmonary bypass: a study in the complement-deficient dog

A M Gillinov1, J M Redmond, J A Winkelstein

  • 1Division of Cardiac Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland.

Summary

Complement component C3 deposition during cardiopulmonary bypass (CPB) increases neutrophil activation and lung sequestration. C3 deficiency reduces these inflammatory responses, highlighting C3

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