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Evidence for an age-dependent decrease in the immunoreactive prolactin-containing terminals of the median eminence of
P Siaud1, G Barbanel, L Givalois
1Endocrinological Neurobiology Laboratory, URA 1197 CNRS, University of Montpellier II, France.
Abstract:
Labelling patterns of immunoreactive prolactin (IR-PRL)-containing and tyrosine hydroxylase (TH)-containing nerve terminals of the median eminence (ME) were compared in young adult (aged 3 months) and old (aged 24 months) male Wistar rats. In the young rats, IR-PRL- and TH-immunostained fibres extended throughout the external most layer of the ME. In the old rats, a significant decrease in the intensity of labelling of IR-PRL terminals was observed in this layer, with a slight reduction in the extent of labelling. As far as TH terminals were concerned, no difference could be detected between young and old animals.