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Effect of nicotine on swimming exercise in rats
S Temocin1, A Erenmemisoglu, C Suer
1Department of Physiology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
The Japanese Journal of Physiology
|January 1, 1993
Abstract:
In this study, endurance time in swimming exercise was evaluated in rats. Subcutaneous (S.C.) injection of nicotine decreased the endurance time in swimming exercise significantly, in a dose-dependent manner compared to the control group. At the dose of 0.125 mg/kg nicotine, the endurance time in swimming exercise remained unchanged, while at the doses of 0.25 and 0.375 mg/kg, it decreased significantly (p < 0.05 and p < 0.01, respectively). This effect of nicotine was antagonized by pretreatment with hexamethonium 5 mg/kg S.C. These results suggest that nicotine may limit the physical performance.