Related Experiment Videos
Autoinhalation of nitric oxide after endogenous synthesis in nasopharynx
H Gerlach1, R Rossaint, D Pappert
1Clinic for Anaesthesiology and Intensive Care Medicine, University Clinic Rulolf Virchow, Berlin, Germany.
Abstract:
Exogenous nitric oxide (NO) reduces pulmonary vascular resistance after low-dose inhalation in patients. To estimate endogenous NO synthesis in the upper respiratory tract, we measured inhaled and exhaled NO in volunteers and patients during spontaneous or controlled ventilation, respectively. 20.3 nmol per min NO was synthesised in the nasopharynx of non-smoking volunteers, leading to autoinhalation of 0.07-0.13 NO parts per million during inspiration; smokers had reduced NO synthesis. In volunteers, 50-70% of the NO was resorbed by the lungs; ventilated patients were deprived of NO autoinhalation. Bacteria in the nose may take part in endogenous NO synthesis.