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Genital human papillomavirus infections in Taiwan
1Department of Microbiology and Immunology, National Defense Medical Center, Taipei, Taiwan, China.
Objectives:
Identification and typing of HPV infections in genital condyloma and normal cytological cervix.
Methods:
Cervical cells from 289 Pap cases with normal cytological findings were examined for HPV infection by slot blot hybridization. Fifteen condyloma biopsy specimens were studied by Southern blot hybridization.
Results:
Thirty-six cases (12.5%) with normal cervical cytology were HPV positive. The predominant HPV type in women with normal cytology is HPV-16. Risk factors for HPV infection in women with normal cytology depend on age and history of pregnancies. Twelve cases (80%) of condyloma contained HPV-6 or -11 sequences. The predominant HPV type in genital condyloma is HPV-11.
Conclusions:
HPV detection in population-based screening programs for cervical neoplasia can be an important tool in identifying women who are at risk of developing dysplasia and cervical cancer.