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Related Experiment Videos

Somatostatin in eating disorders

K M Pirke1, E Friess, M B Kellner

  • 1Department of Psychoendocrinology, University of Trier, Germany.

The International Journal of Eating Disorders
|January 1, 1994
PubMed
Summary

Patients with anorexia nervosa show elevated somatostatin levels after a meal, potentially impacting insulin secretion and gastric emptying. This hormone response differs significantly compared to healthy individuals.

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Area of Science:

  • Endocrinology
  • Gastroenterology
  • Neuroscience

Background:

  • Eating disorders like anorexia nervosa are associated with altered physiological responses.
  • Somatostatin plays a crucial role in regulating gastrointestinal functions and hormone secretion.
  • Previous studies suggest abnormalities in insulin secretion and gastric emptying in patients with eating disorders.

Purpose of the Study:

  • To investigate plasma somatostatin concentrations in response to a standardized meal.
  • To compare somatostatin responses in patients with anorexia nervosa, weight-recovered anorectics, obese women, and healthy controls.
  • To explore the potential link between somatostatin alterations and known gastrointestinal dysfunctions in eating disorders.

Main Methods:

  • Plasma somatostatin levels were measured before and after a standardized fat and protein-rich fluid test meal.

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  • Participants included patients with anorexia nervosa, weight-recovered anorectic patients, obese women, and healthy controls.
  • Hormone levels were monitored for up to 100 minutes post-meal, with analysis of the area under the response curve.

    • Main Results:

    • Somatostatin levels significantly increased in all four groups after the test meal, remaining elevated for up to 100 minutes.
    • Anorectic patients exhibited a significantly higher somatostatin response area under the curve compared to healthy controls and weight-recovered patients (p < .01).
    • Obese women displayed blunted somatostatin responses compared to other groups.

    Conclusions:

    • Elevated postprandial somatostatin in anorexia nervosa may contribute to altered insulin secretion and gastric emptying.
    • The distinct somatostatin response patterns in different groups highlight potential pathophysiological differences in eating disorders and obesity.
    • Further research is warranted to fully elucidate the role of somatostatin in the complex pathophysiology of eating disorders.