Related Experiment Videos
[Inhibitory effect of selenium on complement activation and its clinical significance]
1Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing.
Zhonghua Yi Xue Za Zhi
|November 1, 1993
Summary
Sodium selenite effectively inhibits complement activation in vitro and in vivo, particularly the alternative pathway. This compound significantly reduced mortality in severe epidemic hemorrhagic fever (EHF) cases.
Area of Science:
- Immunopathology
- Complement System Biology
- Trace Element Research
Context:
- Complement activation plays a key role in immunopathology.
- The alternative pathway is a crucial component of the complement system.
- Epidemic hemorrhagic fever (EHF) is a severe condition with high mortality.
Purpose:
- To investigate the inhibitory effect of sodium selenite on complement activation.
- To evaluate the efficacy of sodium selenite in treating severe cases of epidemic hemorrhagic fever (EHF).
Summary:
- Sodium selenite demonstrated a significant inhibitory effect on complement activation in vitro and in vivo, affecting the alternative pathway.
- Effective inhibition was observed at concentrations of 0.002 mol/L in vitro and 20 µg/25g body weight intravenously in vivo.
- In a clinical study of 80 severe EHF cases, daily sodium selenite treatment reduced C3 activation and markedly decreased mortality rates.
Impact:
- Sodium selenite shows potential as a therapeutic agent for complement-mediated diseases.
- The findings suggest a novel treatment strategy for epidemic hemorrhagic fever (EHF), improving patient outcomes.
- This research highlights the immunomodulatory role of selenium in pathological conditions.