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Stability of DNA fingerprint pattern produced with IS6110 in strains of Mycobacterium tuberculosis
M D Cave1, K D Eisenach, G Templeton
1Department of Anatomy, University of Arkansas for Medical Sciences, Little Rock 72205.
Journal of Clinical Microbiology
|January 1, 1994
Abstract:
To assess the stability of IS6110 restriction fragment length polymorphism patterns, DNA fingerprints of 6 Mycobacterium bovis isolates from 1 patient and of 41 Mycobacterium tuberculosis isolates from 18 patients were compared. The fingerprint pattern for a given patient remained identical or nearly identical despite recovery of the isolates during intervals which ranged from 8 months to 4.5 years. Changes in drug resistance profile did not alter a strain's fingerprint pattern.