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[Bacterial adhesion and biofilm]

H Kobayashi1, H Watanabe, N Ohgaki

  • 11st Department of Internal Medicine, Kyorin University, School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|February 1, 1994
PubMed
Summary
This summary is machine-generated.

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Bacteria adhere to tissues via specific and non-specific mechanisms. Bacterial biofilms form, resisting treatment and causing recurrent infections due to sessile bacteria release.

Area of Science:

  • Microbiology
  • Colloidal Chemistry
  • Biomaterials Science

Context:

  • Understanding bacterial adhesion to biological and medical surfaces is crucial.
  • The Derjaguin-Landau-Verwey-Overbeek (DLVO) theory explains non-specific bacterial adhesion.
  • Bacterial biofilms, formed after initial adhesion and glycocalyx production, pose significant clinical challenges.

Purpose:

  • To elucidate the mechanisms of bacterial adhesion to tissues.
  • To describe the formation and characteristics of bacterial biofilms.
  • To highlight the clinical implications of biofilm-associated infections.

Summary:

  • Bacteria initially adhere to surfaces through specific and non-specific interactions, with the latter explained by DLVO theory.
  • Adherent bacteria produce glycocalyx, leading to aggregation and the formation of robust bacterial biofilms on tissues and medical devices.

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  • These biofilms exhibit high resistance to antimicrobial agents, phagocytes, and immunoglobulins, complicating treatment.

    • Impact:

    • Biofilm infections are characterized by intractability and recurrence.
    • The release of sessile bacteria from biofilms leads to persistent and reoccurring infections.
    • This understanding is vital for developing novel strategies to combat biofilm-related diseases.