Related Experiment Videos
A loading-dose strategy for converting from oral to depot haloperidol
L Ereshefsky1, G Toney, S R Saklad
1University of Texas Health Science Center, San Antonio 78284.
Hospital & Community Psychiatry
|December 1, 1993
Summary
A new loading-dose regimen for haloperidol decanoate is safe and effective for initiating depot medication. This method improved clinical outcomes and reduced side effects in patients transitioning from oral haloperidol.
Area of Science:
- Psychopharmacology
- Clinical Neuroscience
Background:
- Depot antipsychotics offer advantages in medication adherence for chronic mental illness.
- Transitioning patients from oral to depot formulations requires careful dose management.
Purpose of the Study:
- To assess the safety and efficacy of a loading-dose regimen for initiating haloperidol decanoate.
- To evaluate this regimen in patients previously maintained on oral haloperidol.
Main Methods:
- 16 patients received a loading dose of haloperidol decanoate (approx. 20x oral dose) over two weeks.
- Dose was gradually reduced; no supplemental oral medication was used.
- Plasma levels, illness severity, and side effects were monitored.
Main Results:
- Loading-dose group showed significant clinical improvement and fewer side effects by day 28.
- Control groups with lower initial doses had varied outcomes, with one group relapsing.
- Therapeutic response was maintained in the loading-dose group.
Conclusions:
- The loading-dose regimen for haloperidol decanoate initiation is safe and effective.
- This approach can be clinically useful for transitioning patients to depot antipsychotics.