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The dopaminergic innervation of monkey entorhinal cortex
Cerebral Cortex (New York, N.Y. : 1991)
|November 1, 1993
Summary
This study maps dopamine (DA) axon organization in the primate entorhinal cortex (ERC). Findings reveal complex, specific patterns of DA innervation across ERC regions and layers, offering insights into dopamine
Area of Science:
- Neuroscience
- Neuroanatomy
- Dopaminergic Systems
Background:
- Dopamine is implicated in schizophrenia pathophysiology.
- The entorhinal cortex (ERC) shows structural pathology in schizophrenia.
- Dopaminergic (DA) innervation of the primate ERC is poorly understood.
Purpose of the Study:
- To determine the organization of DA axons in the macaque monkey ERC.
- To investigate the regional and laminar distribution of DA innervation within the ERC.
Main Methods:
- Utilized immunohistochemical methods with antibodies against tyrosine hydroxylase (TH) and dopamine.
- Employed double-labeling experiments to validate antibody specificity for DA axons.
- Analyzed fiber distribution in cytoarchitectonically identified ERC subdivisions.
Main Results:
- Demonstrated complex, non-uniform DA innervation patterns in the monkey ERC.
- Identified significant rostral-to-caudal and medial-to-lateral gradients in fiber density.
- Revealed distinct laminar distributions of DA fibers across different ERC subdivisions.
Conclusions:
- The DA innervation of the monkey ERC is intricate and exhibits specific regional and laminar organization.
- These patterns suggest potential interactions between DA axons and ERC circuitry.
- Findings may illuminate the functional roles of dopamine in the ERC in health and disease.