Related Experiment Video
Updated: Oct 23, 2026

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
Published on: January 7, 2014
Chronic intoxication of organophosphorus pesticide and its treatment
1Department of Ophthalmology, School of Medicine, Kitasato University, Kanagawa, Japan.
Abstract:
Clinical manifestations of chronic intoxication due to organophosphorus pesticide (OP) and treatment by prifinium bromide, an anticholinergic drug (Padrin), have been introduced. All patients showed oculopathy, mainly neuro-ophthalmological impairments such as: 1. optic neuropathy, 2. degeneration of the retina, 3. defective vertical smooth pursuit, 4. myopia; spasm or paresis of accommodation with or without corneal astigmatism "with the rule" and mild general neurological impairments. These manifestations were more severe among children than in adults, who were environmentally exposed mainly to 3% Malathion sprayed by helicopters several times a year for over 3-5 years. Presumed intake of Malathion for a given child is a far lower dosage than considered previously. Padrin (prifinium bromide) with vitamin B12, C, and E were effective in regressing oculopathy exposed environmentally to OP pesticides.
More Related Videos
08:49Vegetated Treatment Systems for Removing Contaminants Associated with Surface Water Toxicity in Agriculture and Urban Runoff
Published on: May 15, 2017
10:35Study on the Metabolism of Six Systemic Insecticides in a Newly Established Cell Suspension Culture Derived from Tea (Camellia Sinensis L.) Leaves
Published on: June 15, 2019
Related Concept Videos
Prevention of Further Absorption of Poison
Indirect-Acting Cholinergic Agonists: Mechanism of Action
Reversible inhibitors like edrophonium bind to a specific part of the enzyme called the anionic catalytic site. They form noncovalent bonds, which means they are not strongly attached to the enzyme. This creates a temporary and less stable enzyme–inhibitor complex, leading to...
Indirect-Acting Cholinergic Agonists: Pharmacokinetics
Reversible agents containing quaternary amines, such as neostigmine and edrophonium, are not easily absorbed orally because they are...
Anticholinesterase Agents: Poisoning and Treatment
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is slower than the...
Pharmaceutical Poisoning: Treatment Strategies
Microbial Bioremediation of Pesticides