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Endothelial changes in human donor corneas

B Schimmelpfennig, F Bigar, R Witmer

    Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe'S Archive for Clinical and Experimental Ophthalmology
    |January 1, 1976
    PubMed
    Summary
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    Specular microscopy revealed diverse morphologic changes in the corneal endothelium of donor eyes. These findings, classified systematically, align with prior animal and microscopic studies.

    Area of Science:

    • Ophthalmology
    • Cell Biology
    • Microscopy

    Background:

    • The corneal endothelium is crucial for maintaining corneal clarity.
    • Understanding endothelial morphology is vital for transplantation and disease research.

    Purpose of the Study:

    • To systematically classify morphologic changes in the corneal endothelium.
    • To compare findings in human donor corneas with existing literature.

    Main Methods:

    • Specular microscopy was used to examine the corneal endothelium.
    • A series of 278 intact donor eyes were analyzed.

    Main Results:

    • Diverse morphologic changes were observed in the corneal endothelium.
    • These alterations were systematically described and categorized.

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    Conclusions:

    • The observed endothelial changes in human donor corneas are consistent with experimental animal models.
    • Findings support previous light- and electron-microscopic studies.