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Published on: September 14, 2014
Selective effects of human immunodeficiency virus (HIV) gp120 on invertebrate neurons
G B Stefano1, M Sawada, E M Smith
1Old Westbury Neuroscience Research Institute, State University of New York at Old Westbury 11568-0210.
Abstract:
1. HIV gp120 selectively reduces the glutamate-induced inward current and the acetylcholine-induced outward current in specific and identified Aplysia neurons without affecting dopamine (DA)- and serotonin (5-HT)-induced responses. 2. gp120 specifically decreases DA levels without significantly altering norepinephrine and 5-HT levels in Mytilus pedal ganglia. 3. The gp120-associated decrease in DA levels in Mytilus is dose dependent and exhibits a threshold level. 4. The alteration of in vitro DA levels is specific for gp120 since anti-gp120 blocks the effect. 5. gp120 and its effects appear to be stable due to the duration of treatment and the failure of secondary effects to materialize following antibody treatment.
