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Azithromycin prophylaxis against a chloroquine-resistant strain of Plasmodium falciparum
R A Kuschner1, D G Heppner, S L Andersen
1Division of Communicable Diseases, Walter Reed Army Institute of Research, Washington, DC 20307.
Abstract:
Azithromycin has antimalarial activity and favourable pharmacokinetic properties for a prophylactic antimalarial agent. We investigated the ability of azithromycin to prevent malaria in volunteers infected with a chloroquine-resistant strain of Plasmodium falciparum. 4 volunteers received oral azithromycin 500 mg followed by 250 mg daily for 7 further days. Subjects were infected on the third day of azithromycin. 3 subjects were protected compared with none of 15 controls. The volunteer not protected by azithromycin had unquantifiable plasma levels of azithromycin, probably because of poor absorption. Azithromycin could be a promising prophylactic agent for P falciparum malaria.