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Urinary bladder dysfunction in spontaneously diabetic Chinese hamsters

H Itoh1, A Morikawa, I Makino

  • 1Second Department of Internal Medicine, Asahikawa Medical College, Japan.

Diabetes Research and Clinical Practice
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

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Diabetic Chinese hamsters (CHAD) exhibit urinary bladder dysfunction, including increased bladder weight and incomplete voiding. This dysfunction stems from autonomic neuropathy, not muscle issues.

Area of Science:

  • Urology
  • Diabetology
  • Neuroscience

Background:

  • Spontaneously diabetic Chinese hamsters (CHAD) serve as a model for diabetes complications.
  • Diabetic complications can affect various organ systems, including the urinary tract.

Purpose of the Study:

  • To investigate urinary bladder dysfunction in CHAD.
  • To determine the underlying cause of bladder dysfunction in CHAD, differentiating between neuropathy and myopathy.

Main Methods:

  • Comparative analysis of urinary bladder weight and function in diabetic (CHAD) and non-diabetic hamsters.
  • In vivo urodynamic studies involving bladder saline infusion and anesthesia.
  • Assessment of acetylcholinesterase activity and staining in bladder walls.
  • In vitro assessment of bladder pressure response to bethanechol stimulation.

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Main Results:

  • CHAD showed significantly increased bladder wet weight compared to controls.
  • Diabetic hamsters exhibited a higher threshold volume for micturition, decreased contraction amplitude, and incomplete voiding.
  • Overflow incontinence was prevalent in older CHAD.
  • Reduced acetylcholinesterase staining and activity were observed in CHAD bladder walls.
  • Bethanechol-induced bladder pressure responses were similar in both groups, indicating preserved detrusor muscle function.

Conclusions:

  • CHAD develop significant urinary bladder dysfunction.
  • The dysfunction is characterized by impaired micturition and incontinence.
  • Findings strongly suggest diabetic autonomic neuropathy, not detrusor myopathy, as the cause of bladder dysfunction in CHAD.