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Serotonin in panic disorder and social phobia
D V Sheehan1, B A Raj, R R Trehan
1Institute for Research in Psychiatry, University of South Florida, Tampa 33613.
International Clinical Psychopharmacology
|November 1, 1993
Summary
Serotonin
Area of Science:
- Psychiatry
- Neuroscience
- Pharmacology
Background:
- The role of serotonin in psychiatric disorders has been debated for decades.
- Existing literature reviews hypotheses on serotonin's involvement in panic disorder.
Purpose of the Study:
- To review the literature on serotonin's role in panic disorder.
- To address key questions regarding serotonin system defects and treatment efficacy.
Main Methods:
- Literature review of studies published since 1966.
- Analysis of hypotheses and treatment outcomes related to serotonin.
Main Results:
- The precise role of serotonin in panic disorder remains uncertain.
- Increasing evidence suggests serotonin selective uptake inhibitors (SSUIs) are effective for panic disorder.
Conclusions:
- Further double-blind, placebo-controlled studies are necessary to confirm SSUIs' efficacy.
- The exact mechanism of SSUIs in treating panic disorder requires elucidation.