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Paclitaxel (Taxol) treatment for refractory ovarian cancer: phase II clinical trial
V L Seewaldt1, B E Greer, J M Cain
1Department of Medicine, University of Washington Medical Center 98155.
Objective:
Our aim was to determine the efficacy and toxicity of paclitaxel in the treatment of refractory and platinum-resistant epithelial ovarian cancer.
Study Design:
Eligibility required three prior failed chemotherapy regimens and documented platinum resistance. One hundred patients with advanced ovarian cancer received paclitaxel 135 mg/m2 over 24 hours every 21 days with optional granulocyte colony-stimulating factor support.
Results:
Paclitaxel was generally well tolerated. In four patients bowel perforation or fistula developed. After three cycles 34% of patients had stable disease and 25% of patients demonstrated a response, either partial or complete. After six cycles 24% of patients continued to respond. To date, six patients have achieved a complete response.
Conclusion:
A 25% response rate in patients with refractory ovarian cancer was observed, which was durable to six cycles.