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Foscarnet for suppression of human immunodeficiency virus replication
C V Fletcher1, A C Collier, F S Rhame
1Department of Pharmacy Practice, University of Minnesota, Minneapolis.
Antimicrobial Agents and Chemotherapy
|March 1, 1994
Abstract:
The effect of foscarnet against human immunodeficiency virus (HIV) was evaluated in nine HIV-infected individuals; six completed 28 days of induction therapy. The overall mean increase in CD4+ lymphocytes was 64 cells per mm3. The mean decline in the HIV antigen concentration was 108 pg/ml (P = 0.03), and suppression was related to systemic foscarnet exposure by a maximum-effect pharmacodynamic model.