The origin of lysyl oxidase

¹Department of Obstetrics and Gynecology, C.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI 48201.

Comparative Biochemistry and Physiology. Biochemistry and Molecular Biology

|May 1, 1994

Abstract:

Lysyl oxidase initiates crosslink formation of the collagen and elastin extracellular matrix, thereby delimiting its expansive properties. Recently lysyl oxidase has been cloned from several species enabling the computation of the relative order of appearance of the various components of this enzyme system. Comparative evolutionary computer-assisted sequence analysis of the enzyme and its various substrates was undertaken to address this issue. These results support the ordered genesis of the collagen substrate-->lysyl oxidase enzyme-->elastin substrate.

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