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Histamine effect on human cutaneous blood flow: regional variations
1Department of Dermatology, Elias-Sourasky Medical Center, Tel Aviv University, Israel.
Acta Dermato-Venereologica
|March 1, 1994
Summary
Cutaneous blood flow responses to histamine vary by body site, with the back showing a greater response than the forearm and ankle. These findings highlight regional differences in small blood vessel reactivity.
Area of Science:
- Dermatology
- Physiology
- Pharmacology
Background:
- Histamine elicits varied cutaneous responses, potentially due to regional differences in small blood vessel reactivity.
- Understanding these variations is crucial for interpreting skin reactions to endogenous and exogenous substances.
Purpose of the Study:
- To investigate the regional dependence of cutaneous blood flow in response to histamine.
- To compare histamine-induced responses across different anatomical sites (back, forearm, ankle).
Main Methods:
- Histamine was administered intradermally (prick test) and topically to 20 volunteers across three body sites.
- Cutaneous blood flow was quantified using laser Doppler flowmetry.
- Response extent and time parameters were analyzed, comparing intradermal and topical methods.
Main Results:
- Significant differences in blood flow response were observed: back > forearm > ankle (p < 0.01 prick test).
- Intradermal administration resulted in a faster onset of maximum response compared to topical application.
- No significant gender-based variations or differences in response time parameters were found across sites.
Conclusions:
- Regional variations in cutaneous blood flow response to histamine exist, suggesting inherent functional differences in small blood vessels.
- These findings may offer insights into the pathophysiology of various skin conditions and diseases.