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Renal transplantation: a twenty-five year experience
Annals of Surgery
|November 1, 1976
Summary
Boston pioneered renal transplantation, achieving breakthroughs like the first successful allografts and introducing key immunosuppressive drugs. This led to significant patient survival rates, with 68% of recipients alive today.
Area of Science:
- Nephrology
- Transplantation Surgery
- Immunosuppression
Background:
- Boston's historical contributions to renal transplantation.
- Key milestones include the first successful isograft (1954), allograft from fraternal twins (1959), and cadaveric donor (1962).
Observation:
- Development and application of novel immunosuppressive drugs in Boston (1959-1962).
- By 1965, renal transplantation became a clinical reality.
Findings:
- Remarkable 68% survival rate among 589 recipients since 1950.
- Living-related donor transplants show higher graft survival (68%) compared to cadaveric (39%).
- One-year survival rates: 80% for living-related vs. 50% for cadaveric donors since 1968.
Implications:
- Boston's foundational role in advancing renal transplant success.
- Improved patient outcomes and graft longevity through advancements in immunosuppression and donor matching.
- Excellent psychosocial rehabilitation observed in 79% of one-year survivors, highlighting holistic patient recovery.