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Neuroleptics differentially induce jun family genes in the rat striatum
1Laboratoire de Neurobiologie Moléculaire des Interactions Cellulaires UPR 416 du CNRS, Centre de Neurochimie, Strasbourg, France.
Neuroreport
|January 12, 1994
Abstract:
The effect of neuroleptics in single administration on the expression of genes of the jun family was studied in the rat striatum. jun B, but not jun D was dose-dependently and transiently induced. This effect was blocked by pretreatment with a specific dopamine D2 agonist. The expression of c-jun was also stimulated, although this did not reach statistical significance. Thus dopamine D2 receptors differentially regulate the expression of jun family members in the striatum.