Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Neurogenic inflammation]

M Ichinose1, M Miura, T Takahashi

  • 1First Department of Internal Medicine, Tohoku University School of Medicine.

Nihon Kyobu Shikkan Gakkai Zasshi
|December 1, 1993
PubMed
Summary

Airway neurogenic inflammation, linked to asthma, involves sensory nerves releasing neuropeptides. Tachykinin receptor antagonists show promise in controlling this inflammation and protecting against airway narrowing in asthma patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hepatocyte growth factor is linked by O-glycosylated oligosaccharide on the alpha chain.

Biochemical and biophysical research communications·1992
Same author

Reappraisal of the coupling interval of ventricular extrasystoles as an index of ectopic mechanisms.

British heart journal·1992
Same author

Toxicity studies of the non-sulfhydryl angiotensin converting enzyme inhibitor N-[8-amino-1(S)-carboxyoctyl]-L-alanyl-L-proline in rats.

Arzneimittel-Forschung·1992
Same author

Pulmonary blastoma. Comparison between its epithelial components and fetal bronchial epithelium.

Acta pathologica japonica·1992
Same author

Site-directed mutagenesis of amino acid residues involved in the glutathione binding of human glutathione S-transferase P1-1.

Journal of biochemistry·1992
Same author

Effects of sialagogues on ornithine decarboxylase induction and proto-oncogene expression in murine parotid gland.

Journal of dental research·1992

Area of Science:

  • Respiratory Medicine
  • Neuroimmunology
  • Pharmacology

Background:

  • Airway neurogenic inflammation, implicated in asthma pathogenesis, stems from neuropeptide release by airway sensory nerves.
  • Stimuli for airway sensory nerves include bradykinin, leukotrienes, hyperventilation, and cigarette smoke.

Purpose of the Study:

  • To investigate the role of endogenously released tachykinins in asthmatic airways.
  • To evaluate the efficacy of tachykinin receptor antagonists in managing airway neurogenic inflammation and bronchoconstriction.

Main Methods:

  • Review of mechanisms of airway neurogenic inflammation.
  • Analysis of presynaptic modulation of airway sensory nerves.
  • Clinical assessment of tachykinin receptor antagonist effects in asthmatic patients.

Related Experiment Videos

Main Results:

  • Presynaptic modulation via opioids, histamine H3-agonists, NPY, and potassium channel openers effectively controls neurogenic inflammation.
  • Tachykinin receptor antagonists demonstrate inhibitory effects on airway neurogenic inflammation.
  • Pretreatment with a tachykinin receptor antagonist protected asthmatic patients against bradykinin-induced airway narrowing.

Conclusions:

  • Endogenously released tachykinins play a significant functional role in the airways of individuals with asthma.
  • Tachykinin receptor antagonists represent a potential therapeutic strategy for asthma management by targeting neurogenic inflammation.