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Updated: Aug 13, 2026

Burn Injury-Induced Pain and Depression-Like Behavior in Mice
Published on: September 29, 2021
[State of neuroendocrine systems and immunity in patients with burns]
Abstract:
The study of hormonal shifts and immunity in 95 patients with burns has revealed hyperergic reaction of the neuroendocrine system in the early period after trauma, accompanied by a marked and prolonged inhibition of cellular and humoral immunity. The use of antistress agents (clofelin, pentamine) and intravenous laser blood irradiation leads to a more prompt arrest of hyperergic reaction of the neuroendocrine system and to the reduction of immunosuppressing effect of burn trauma, which decreases the number of pyoseptic complications from 26.4 to 16% and total lethality from 16 to 3.8%.
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