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Psoralen-fatty acid cycloadducts activate protein kinase C (PKC) in human platelets
S Caffieri1, M Ruzzene, B Guerra
1Department of Pharmaceutical Sciences of the University, Padua, Italy.
Journal of Photochemistry and Photobiology. B, Biology
|March 1, 1994
Abstract:
The C4-photocycloadduct psoralen-linolenic acid activates protein kinase C (PKC), in human platelets, which in turn phosphorylates 47 kDa protein, representing its major substrate in these cells. This behaviour is similar to that shown by diacylglycerol, a main second messenger responsible of various biological effects, e.g. of melanogenesis.