[Hematopoiesis and grafts of hematopoietic stem cells]

The human hematopoiesis produces daily in the bone marrow several billions of blood cells. Bone marrow cells could be classified in three categories: the pluripotent stem cells able to self renewal and to differentiate in every kind of blood cell lineage, the progenitors, already engaged in one cell lineage and precursors, already recognizable on the bone marrow smear. This hematopoietic mechanism is controlled by a complex network of stimulating and inhibitory molecules. We report the interest of such basic research in the establishment of hematopoietic stem cell transplantation, their in vitro treatment and their selection. We point out the value of these laboratory technics for autografting monitoring.