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Related Experiment Videos

Changes in brain neurotransmitters in rodent malaria

S Roy1, R N Chattopadhyay, S K Maitra

  • 1Department of Physiology with Community Development, Vidyasagar University, Midnapore, India.

Indian Journal of Malariology
|December 1, 1993
PubMed
Summary

Malaria infection in rodents significantly reduced brain serotonin (5-hydroxytryptamine) and norepinephrine levels. These neurotransmitter changes may contribute to cerebral vasodilatation during malaria.

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Area of Science:

  • Neuroscience
  • Parasitology
  • Biochemistry

Background:

  • Malaria, caused by Plasmodium parasites, can affect brain function.
  • Neurotransmitter imbalances are implicated in various neurological conditions.

Purpose of the Study:

  • To investigate the impact of Plasmodium berghei infection on key brain neurotransmitters.
  • To explore potential links between neurotransmitter changes and malaria-induced cerebral effects.

Main Methods:

  • Studied neurotransmitter levels (5-hydroxytryptamine, norepinephrine, histamine, dopamine) in the brains of infected mice and rats.
  • Utilized biochemical assays to quantify neurotransmitter concentrations.

Main Results:

  • Significant decreases in brain 5-hydroxytryptamine (5-HT) and norepinephrine were observed in infected rodents.
  • Brain histamine and dopamine levels remained unchanged compared to controls.

Conclusions:

  • Plasmodium berghei infection alters specific brain neurotransmitter levels, notably reducing 5-HT and norepinephrine.
  • The observed decrease in 5-HT and norepinephrine may play a role in the cerebral vasodilatation associated with malaria.

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