Related Experiment Video
Updated: Aug 23, 2026

Genetic Studies of Human DNA Repair Proteins Using Yeast as a Model System
Published on: March 18, 2010
Genetic activity of bleomycin: differential effects on mitotic recombination and mutations in yeast
Abstract:
The genetic effects of the antitumor antibiotic, bleomycin were studied in different strains of Saccharomyces cerevisiae. It was observed that the drug induced a high frequency of mitotic recombination and gene conversion. In contrast, it produced only a few mutations from adenine independence to adenine dependence and histidine dependence (a missense mutant) to histidine independence. In the strains carrying ochre-suppressible auxotrophic markers, no prototrophs were induced by this drug. The results indicating the specific activity of bleomycin are discussed and, in this connection, the usefulness of yeast as a test organism in mutagenicity screening is emphasized.
More Related Videos
Related Concept Videos
Gene Conversion
Conservative Site-specific Recombination and Phase Variation
The recognition sites for Cre recombinase called LoxP...
Mismatch Repair
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
Crossing Over
Spontaneous and Induced Mutations

