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Antideficit properties of neuroleptics
1Department of Psychiatry, Rouen School of Medicine, France.
Acta Psychiatrica Scandinavica. Supplementum
|January 1, 1994
Summary
Neuroleptics show a dual effect: antidelusional in the US and a beneficial disinhibiting action on negative schizophrenia symptoms in Europe. Double-blind studies confirmed this European finding, particularly with sulpiride and amisulpiride.
Area of Science:
- Psychiatry
- Pharmacology
Background:
- The antidelusion effect of neuroleptics is emphasized in US research.
- European research identified a distinct beneficial effect on negative schizophrenia symptoms, termed disinhibitor, stimulant, antiautistic, and anti-deficit.
Purpose of the Study:
- To review the historical development and evidence for the beneficial effects of certain neuroleptics on negative symptoms of schizophrenia, particularly in European research.
Main Methods:
- Historical review of clinical observations and classifications (1952-1976).
- Pharmacological and biochemical research (1976-1984).
- Confirmation through double-blind studies (1984-1989).
Main Results:
- Early studies noted various beneficial effects on negative symptoms.
- Pharmacological and biochemical research elucidated mechanisms.
- Double-blind studies confirmed the disinhibiting effect of low-dose sulpiride and amisulpiride.
Conclusions:
- A distinct beneficial effect of certain neuroleptics on negative schizophrenia symptoms, separate from the antidelusion effect, has been established.
- This effect, particularly the disinhibiting action, is supported by robust clinical and pharmacological evidence.