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MDR1 gene expression in chronic lymphocytic leukemia
J Wallner1, H Gisslinger, B Gisslinger
1Clinic for Internal Medicine I, University of Vienna Medical School, Austria.
Leukemia & Lymphoma
|April 1, 1994
Summary
The MDR1 gene
Area of Science:
- Hematology
- Molecular Biology
- Oncology
Background:
- The MDR1 gene plays a role in multidrug resistance.
- Its role in chronic lymphocytic leukemia (CLL) requires further investigation.
Purpose of the Study:
- To assess the clinical significance of MDR1 gene expression in chronic lymphocytic leukemia (CLL).
Main Methods:
- MDR1 RNA expression was quantified in 39 CLL patients.
- Correlations were analyzed with clinical parameters and p53 expression.
- P-glycoprotein expression was assessed via immunocytochemistry.
Main Results:
- MDR1 RNA expression was detected in 29 patients and correlated with white blood cell count and MDR2 RNA.
- MDR1 RNA expression was significantly associated with p53 expression (P < 0.001).
- P-glycoprotein expression on leukemic cells correlated with MDR1 RNA expression (P = 0.048).
Conclusions:
- MDR1 gene expression in CLL is linked to p53 expression and P-glycoprotein presence.
- MDR1 RNA levels are independent of patient age, treatment status, and clinical stage.