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[Mivazerol and other benzylimidazoles with alpha-2 adrenergic properties]
E Cossement1, J P Geerts, P Michel
1Département de Recherche Chimique, R&D, UCB S.A. Secteur Pharmaceutique Chemin du Foriest, Belgique.
Journal De Pharmacie De Belgique
|May 1, 1994
Abstract:
4-Benzyl-imidazole compounds derived from Salbutanol are evaluated for potential adrenergic activities. The prevalent property of a series of new bioisosteres of catecholamines either of the saligenol-(ucb LO61) or benzamide-(Mivazerol) type is a selective alpha-adrenergic agonism, at the presynaptic level. The present study stresses the structural features responsible for the alpha-2-agonistic property.