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Signals transduced through the CD4 molecule on T lymphocytes activate NF-kappa B

N Chirmule1, V S Kalyanaraman, S Pahwa

  • 1Department of Pediatrics, North Shore University Hospital-Cornell University Medical College, Manhasset, NY 11030.

Biochemical and Biophysical Research Communications
|August 30, 1994
PubMed
Summary

Native HIV-1 envelope glycoproteins (gp160) activate the NF-kappa B transcription factor via CD4 molecules. This activation involves specific proteins and signaling pathways, potentially influencing HIV replication and immune responses.

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