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Noradrenergic modulation of avian kidney function

D Jungbluth1, C Simon-Oppermann, H Schütz

  • 1Max-Planck-Institut für Physiologische und Klinische Forschung, W.G. Kerckhoff-Institut, Bad Nauheim, F.R.G.

Comparative Biochemistry and Physiology. Comparative Physiology
|May 1, 1994
PubMed
Summary

Norepinephrine (NE) causes high blood pressure and increased urine output in ducks. This suggests pressure diuresis, potentially involving atrial natriuretic factor, plays a role in regulating fluid balance.

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Area of Science:

  • Physiology
  • Nephrology
  • Endocrinology

Background:

  • Norepinephrine (NE) is a key hormone in cardiovascular and renal regulation.
  • Understanding NE's effects on renal function in non-mammalian vertebrates is crucial for comparative physiology.
  • Previous studies have not fully elucidated the dose-dependent renal and hormonal responses to NE infusion in conscious ducks.

Purpose of the Study:

  • To investigate the dose-dependent effects of norepinephrine infusion on cardiovascular, renal, and hormonal parameters in conscious ducks.
  • To determine the role of pressure diuresis and natriuresis in response to NE.
  • To examine the involvement of osmoregulatory hormones, including atrial natriuretic factor (ANF), in NE-induced renal responses.

Main Methods:

  • Conscious, salt and water-loaded ducks were infused with norepinephrine (NE) at three different doses (0.7, 2.2, 6.7 µg/min/kg).

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  • Arterial blood pressure, heart rate, glomerular filtration rate (GFR), renal blood flow (RBF), and urine output were monitored.
  • Plasma concentrations of antidiuretic hormone (ADH), angiotensin II, and atrial natriuretic factor (ANF) were measured.
  • Sub-pressor doses of NE were infused near the renal arteries to assess localized effects.

    • Main Results:

    • NE infusion dose-dependently increased arterial blood pressure and induced reflex bradycardia.
    • Renal function showed unchanged GFR but reduced RBF with increasing NE doses.
    • NE caused a significant diuresis and natriuresis, with a marked increase in plasma ANF levels.
    • Sub-pressor NE doses near renal arteries induced diuresis without increasing urinary sodium concentration.

    Conclusions:

    • Norepinephrine induces arterial hypertension, reflex bradycardia, and pressure diuresis/natriuresis in ducks.
    • The observed natriuresis may be partly mediated by the significant increase in atrial natriuretic factor.
    • These findings highlight the role of pressure-mediated mechanisms in renal regulation by NE in avian species.