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Later embryogenesis: regulatory circuitry in morphogenetic fields

E H Davidson1

  • 1Division of Biology, California Institute of Technology, Pasadena 91125.

Development (Cambridge, England)
|July 1, 1993
PubMed
Summary
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Regulatory processes guide spatial subdivision of morphogenetic regions during embryogenesis. Intercellular signaling and transcription factors establish progenitor field boundaries, crucial for development.

Area of Science:

  • Developmental Biology
  • Embryogenesis
  • Molecular Biology

Background:

  • Morphogenetic fields are key to embryonic development.
  • Understanding their spatial subdivision is crucial for developmental biology.

Purpose of the Study:

  • To review regulatory mechanisms governing spatial subdivision of morphogenetic regions.
  • To define and analyze progenitor fields in later embryogenesis.

Main Methods:

  • Application of a progenitor field definition.
  • Analysis of sea urchin and Xenopus embryonic development examples.
  • Comparative review across various model organisms (vertebrates, Drosophila, C. elegans, sea urchin).

Main Results:

  • Progenitor fields possess sharp spatial boundaries with distinct cell fates.

Related Experiment Videos

  • Initial boundary formation relies on positive and negative transcription control.
  • Intercellular signaling mediates field specification, boundary organization, and regionalization.

    • Conclusions:

    • Repetitive [signal-->transcription factor gene-->signal] circuits are fundamental regulatory elements.
    • These circuits are utilized across diverse morphogenetic processes.
    • Transcription factors activated by signaling play a critical role in developmental patterning.