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Sero-salivary progesterone correlation

I I Bolaji1

  • 1Academic Department of Obstetrics and Gynaecology, University College Hospital, Galway, Ireland.

International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics
|May 1, 1994
PubMed
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Saliva progesterone levels accurately reflect serum concentrations in normally cycling, pregnant, and postmenopausal women. This non-invasive salivary measurement offers a reliable alternative for endocrine and gynecological studies.

Area of Science:

  • Endocrinology
  • Biochemistry
  • Reproductive Biology

Background:

  • Saliva offers advantages for hormone monitoring.
  • Previous studies suggested salivary sex steroid levels correlate with serum levels.
  • Recent doubts necessitate re-evaluation of this relationship.

Purpose of the Study:

  • To establish the correlation between serum and salivary progesterone.
  • To assess this correlation in quiescent and dynamic physiological states.
  • To validate salivary progesterone as a reliable biomarker.

Main Methods:

  • Serum and salivary progesterone were measured using enzyme immunoassay.
  • Participants included normally cycling (N=23), pregnant (N=10), and postmenopausal women on HRT (N=5).

Related Experiment Videos

  • Non-isotopic enzyme immunoassay on microtiter plates was employed.

    • Main Results:

    • Salivary progesterone was approximately 1% of serum progesterone.
    • A strong positive correlation was observed between serum and salivary progesterone across all groups.
    • Linear regression analysis confirmed significant correlations (r=0.987, P<0.001; r=0.958, P<0.001; r=0.714, P<0.001).
    • Simultaneous peak concentrations in serum and saliva post-therapy in postmenopausal women support rapid ultrafiltration.

    Conclusions:

    • Salivary progesterone measurement reliably reflects serum concentrations.
    • Saliva offers an attractive, non-invasive alternative to serum testing.
    • This method is suitable for gynecological and endocrinological investigations, particularly longitudinal studies.