Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple endocrine neoplasia type IIb: a case report

S Jaruratanasirikul1, N Patarakijvanich, S Patrapinyokul

  • 1Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand.

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
|June 1, 1993
PubMed
Summary

This report details a rare pediatric case of Multiple Endocrine Neoplasia type IIb (MEN IIb), diagnosed in a 14-year-old boy with medullary thyroid carcinoma and mucosal neuromas, highlighting the need for early recognition.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A randomized clinical trial of chlorhexidine in the maintenance of oral candidiasis-free period in HIV infection.

Oral diseases·2008
Same author

Clinics in diagnostic imaging (112). Perinatal lethal hypophosphatasia (PLH).

Singapore medical journal·2006
Same author

Impaired differential renal function in a child with pheochromocytoma.

Journal of human hypertension·2005
Same author

Prenatal diagnosis of a huge cystic hygroma colli.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2003
Same author

Stability of ceftazidime in normal saline solution after exposure to light.

The Southeast Asian journal of tropical medicine and public health·2001
Same author

The clinical course of Hashimoto's thryoiditis in children and adolescents: 6 years longitudinal follow-up.

Journal of pediatric endocrinology & metabolism : JPEM·2001

Area of Science:

  • Pediatric Endocrinology
  • Oncology
  • Genetics

Background:

  • Multiple Endocrine Neoplasia type IIb (MEN IIb) is a rare genetic disorder.
  • It is characterized by medullary thyroid carcinoma, pheochromocytoma, and mucosal neuromas.
  • MEN IIb has a high risk of malignancy and requires early diagnosis.

Observation:

  • A 14-year-old boy presented with a 4-year history of multiple thyroid nodules.
  • Physical examination revealed marfanoid habitus, coarse facies, thick lips, prominent jaw, and mucosal neuromas.
  • Thyroid scan showed multiple cold nodules, later confirmed as medullary thyroid carcinoma.

Findings:

  • Despite typical MEN IIb features, the patient was normotensive with normal 24-hour urinary vanillyl mandelic acid.
  • Adrenal glands appeared normal on computerized tomography.

Related Experiment Videos

  • Diagnosis of MEN IIb was established based on phenotypic features, mucosal neuromas, and medullary thyroid carcinoma.

    • Implications:

    • This case underscores the importance of recognizing MEN IIb in children, even with atypical presentations.
    • Early identification of MEN IIb is crucial for timely intervention and improved patient outcomes.
    • Further research into pediatric MEN IIb is warranted due to its rarity and severity.