Related Experiment Videos
Antipsychotic drugs: is more worse? A meta-analysis of the published randomized control trials
P Bollini1, S Pampallona, M J Orza
1Technology Assessment Group, Harvard School of Public Health, Boston, MA.
Psychological Medicine
|May 1, 1994
Abstract:
Effectiveness and side-effects of high- versus low-dose neuroleptic treatment of chronic psychosis have been assessed through a meta-analysis of 22 published randomized control trials comparing different neuroleptic doses. No incremental clinical improvement was found at doses above 375 mg equivalent of chlorpromazine, while a significant increase in adverse reactions was observed.