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Increased levels of circulating intercellular adhesion molecule-1 in patients with localized scleroderma
1Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan.
Journal of the American Academy of Dermatology
|October 1, 1994
Summary
Serum levels of circulating intercellular adhesion molecule-1 (cICAM-1) were elevated in patients with localized scleroderma. Higher cICAM-1 levels correlated with disease severity and immune markers, suggesting immune activation in localized scleroderma.
Area of Science:
- Immunology
- Dermatology
- Rheumatology
Background:
- Intercellular adhesion molecule-1 (ICAM-1) plays a role in immune responses.
- Circulating ICAM-1 (cICAM-1) may indicate immune activation.
- Localized scleroderma exhibits immunologic abnormalities.
Purpose of the Study:
- To determine if serum cICAM-1 levels are elevated in localized scleroderma patients.
- To investigate correlations between cICAM-1 levels and clinical/serologic features of localized scleroderma.
Main Methods:
- Enzyme-linked immunosorbent assay (ELISA) was used to measure serum cICAM-1.
- Study included 48 patients with localized scleroderma, 20 with systemic sclerosis, and 20 healthy controls.
Main Results:
- Serum cICAM-1 levels were significantly higher in localized scleroderma patients compared to controls.
- Elevated cICAM-1 correlated with lesion count, affected areas, antihistone antibody IgM, and soluble interleukin 2 receptor.
Conclusions:
- Immune activation appears to be a contributing factor in localized scleroderma.
- cICAM-1 may serve as a biomarker for immune activity in localized scleroderma.
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