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Updated: Jul 20, 2026

Spatiotemporal Analysis of Cytokinetic Events in Fission Yeast
Published on: February 20, 2017
The fission yeast cdc18+ gene product couples S phase to START and mitosis
T J Kelly1, G S Martin, S L Forsburg
1Imperial Cancer Research Fund Cell Cycle Group, Biochemistry Department, Oxford University, England.
Abstract:
Commitment to the cell cycle in fission yeast requires the function of the cdc10+ transcriptional activator at START. The product of the cdc18+ gene is a major downstream target of cdc10+, and transcription of cdc18+ is activated by cdc10+ during passage through START. The cdc18+ function is required for entry into S phase. In addition, the product of the cdc18+ gene is part of the checkpoint control that prevents mitosis from occurring until S phase is completed. Thus, cdc18+ plays a key role in coupling S phase to START and mitosis.
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